Design and Analysis of a Cable-Driven Test Apparatus for Flapping-Flight Research

The biology, physiology, kinematics, and aerodynamics of insect flight have been a longstanding fascination for biologists and engineers. The former three are easily obtained through the observation of the organic species. The latter though, is very difficult to study in this fashion. In many cases, aerodynamic forces and fluid-body interactions can be simulated with computational fluid dynamics; another option is to use dynamically-scaled, experimental set-ups to measure physically these values. An archetypal, experimental set-up may include one or two scaled wings, where each wing is actuated to achieve upwards of three degrees of freedom. The three degrees of freedom correspond biologically to the stroke, deviation, and rotation motions of real insects. The wing modules may be fixed to rotate about a central, fourth axis, mimicking the insect body rotation. Alternatively, the wing modules can be fixed to translate in one direction, copying the forward flight pattern of an insect. These experiments usually are performed in a tank of mineral oil, seeded to highlight the fluid\u27s movement. Unfortunately, the current state of experimental apparatuses limit the number and complexity of studiable flight patterns. The goal is to use a subset of robotics called cable-driven parallel manipulators to improve upon and expand the capabilities of these apparatuses. For these robots, rigid links are replaced with tensioned cables and actuated via electric motors. Each cable attaches to the central manipulator platform, similar to other parallel manipulators. Some advantages of a cable-driven design are large position workspaces, low inertia, high manipulator dynamics, large strength-to-weight ratio, and no actuator-error stack-up. Cable manipulators have been researched in the lab and have been deployed commercially, such as at professional sports stadiums. The manipulator uses a standard cuboid frame, with eight winches actuating eight cables. The manipulator platform is a scaled insect body, with each wing capable of three degrees of freedom, and an optimized attachment frame for the cables. The manipulator\u27s workspace for six degrees of freedom was derived from previous works and simulated in MathWorks\u27 MATLAB for a variety of parameterizations. The lead design incorporates a novel, new cable configuration for realizing greater rotational capability over standard cable-driven manipulators. While a standard, Straight cable configuration allows for large translation but almost no rotation, the new Twist cable configuration provides a smaller yet spread out workspace that is sustainable through singular rotations up to at least 45°, as well as simultaneous rotations about multiple axes. Optimal trends for the attachment frame are discerned from comparing a multitude of size permutations for singular rotations. No one attachment frame holds equal rotational potential about all three axes; however, the strengths and weaknesses of an attachment frame easily are adaptable based on the proposed insect maneuver. To showcase the versatility of the apparatus with a 6 in × 2 in × 4 in attachment frame, four different flight maneuvers are analyzed. The first two case studies prove the cable-driven apparatus can combine the individual functions of existing experimental apparatuses: MATLAB simulations show the device can perform a stationary 116° yaw rotation and separately can translate the end effector 32 in along one axis. A third case study investigates a previously published work on an evasive pitching maneuver from a hawkmoth. In the original study, the normally six-degree-of-freedom movement was distilled down to only one-dimensional translation and pitch rotation, such that it could be replicated in the lab. Using the cable-driven apparatus though, it is possible instead to reproduce the generalized, six-degree-of-freedom maneuver. Finally, a conceptual flight pattern is created to demonstrate the unique advantages of the cable-driven apparatus. The flight path models a pitched dive into a banked quarter turn, with a pitched climb upon exiting the turn. The equal necessity and coupling of all degrees of freedom for this maneuver means it cannot be performed on current experimental apparatuses, except for the cable-driven apparatus. This new cable-driven test apparatus, with its unique design and modifications, would improve the capabilities for experimental studies and provide the most realistic set-up for flapping-flight research

Physiological Correlates of Volunteering

We review research on physiological correlates of volunteering, a neglected but promising research field. Some of these correlates seem to be causal factors influencing volunteering. Volunteers tend to have better physical health, both self-reported and expert-assessed, better mental health, and perform better on cognitive tasks. Research thus far has rarely examined neurological, neurochemical, hormonal, and genetic correlates of volunteering to any significant extent, especially controlling for other factors as potential confounds. Evolutionary theory and behavioral genetic research suggest the importance of such physiological factors in humans. Basically, many aspects of social relationships and social activities have effects on health (e.g., Newman and Roberts 2013; Uchino 2004), as the widely used biopsychosocial (BPS) model suggests (Institute of Medicine 2001). Studies of formal volunteering (FV), charitable giving, and altruistic behavior suggest that physiological characteristics are related to volunteering, including specific genes (such as oxytocin receptor [OXTR] genes, Arginine vasopressin receptor [AVPR] genes, dopamine D4 receptor [DRD4] genes, and 5-HTTLPR). We recommend that future research on physiological factors be extended to non-Western populations, focusing specifically on volunteering, and differentiating between different forms and types of volunteering and civic participation

Design and analysis of a cable-driven test apparatus for flapping-flight research

The biology, physiology, kinematics, and aerodynamics of insect flight have been a longstanding fascination for biologists and engineers. The former three are easily obtained through the observation of the organic species. The latter though, is very difficult to study in this fashion. In many cases, aerodynamic forces and fluid-body interactions can be simulated with computational fluid dynamics; another option is to use dynamically-scaled, experimental set-ups to measure physically these values. An archetypal, experimental set-up may include one or two scaled wings, where each wing is actuated to achieve upwards of three degrees of freedom. The three degrees of freedom correspond biologically to the stroke, deviation, and rotation motions of real insects. The wing modules may be fixed to rotate about a central, fourth axis, mimicking the insect body rotation. Alternatively, the wing modules can be fixed to translate in one direction, copying the forward flight pattern of an insect. These experiments usually are performed in a tank of mineral oil, seeded to highlight the fluid\u27s movement. Unfortunately, the current state of experimental apparatuses limit the number and complexity of studiable flight patterns. The goal is to use a subset of robotics called cable-driven parallel manipulators to improve upon and expand the capabilities of these apparatuses. For these robots, rigid links are replaced with tensioned cables and actuated via electric motors. Each cable attaches to the central manipulator platform, similar to other parallel manipulators. Some advantages of a cable-driven design are large position workspaces, low inertia, high manipulator dynamics, large strength-to-weight ratio, and no actuator-error stack-up. Cable manipulators have been researched in the lab and have been deployed commercially, such as at professional sports stadiums. The manipulator uses a standard cuboid frame, with eight winches actuating eight cables. The manipulator platform is a scaled insect body, with each wing capable of three degrees of freedom, and an optimized attachment frame for the cables. The manipulator\u27s workspace for six degrees of freedom was derived from previous works and simulated in MathWorks\u27 MATLAB for a variety of parameterizations. The lead design incorporates a novel, new cable configuration for realizing greater rotational capability over standard cable-driven manipulators. While a standard, Straight cable configuration allows for large translation but almost no rotation, the new Twist cable configuration provides a smaller yet spread out workspace that is sustainable through singular rotations up to at least 45°, as well as simultaneous rotations about multiple axes. Optimal trends for the attachment frame are discerned from comparing a multitude of size permutations for singular rotations. No one attachment frame holds equal rotational potential about all three axes; however, the strengths and weaknesses of an attachment frame easily are adaptable based on the proposed insect maneuver. To showcase the versatility of the apparatus with a 6 in × 2 in × 4 in attachment frame, four different flight maneuvers are analyzed. The first two case studies prove the cable-driven apparatus can combine the individual functions of existing experimental apparatuses: MATLAB simulations show the device can perform a stationary 116° yaw rotation and separately can translate the end effector 32 in along one axis. A third case study investigates a previously published work on an evasive pitching maneuver from a hawkmoth. In the original study, the normally six-degree-of-freedom movement was distilled down to only one-dimensional translation and pitch rotation, such that it could be replicated in the lab. Using the cable-driven apparatus though, it is possible instead to reproduce the generalized, six-degree-of-freedom maneuver. Finally, a conceptual flight pattern is created to demonstrate the unique advantages of the cable-driven apparatus. The flight path models a pitched dive into a banked quarter turn, with a pitched climb upon exiting the turn. The equal necessity and coupling of all degrees of freedom for this maneuver means it cannot be performed on current experimental apparatuses, except for the cable-driven apparatus. This new cable-driven test apparatus, with its unique design and modifications, would improve the capabilities for experimental studies and provide the most realistic set-up for flapping-flight research

HIV-1 in lymph nodes is maintained by cellular proliferation during antiretroviral therapy

To investigate the possibility that HIV-1 replication in lymph nodes sustains the reservoir during ART, we looked for evidence of viral replication in 5 donors after up to 13 years of viral suppression. We characterized proviral populations in lymph nodes and peripheral blood before and during ART, evaluated the levels of viral RNA expression in single lymph node and blood cells, and characterized the proviral integration sites in paired lymph node and blood samples. Proviruses with identical sequences, identical integration sites, and similar levels of RNA expression were found in lymph nodes and blood samples collected during ART, and no single sequence with significant divergence from the pretherapy population was present in either blood or lymph nodes. These findings show that all detectable persistent HIV-1 infection is consistent with maintenance in lymph nodes by clonal proliferation of cells infected before ART and not by ongoing viral replication during ART